Alagille syndrome (ALGS) is a rare, multisystem genetic disorder that can affect the liver, heart, skeleton, eyes, central nervous system, kidneys and facial features. The estimated incidence of ALGS ranges from 1 in 30,000 to 50,000 live births. Liver damage is caused by a paucity of bile ducts preventing bile flow from the liver to the small intestine. Approximately 95% of patients with the condition present with chronic cholestasis, usually within the first three months of life, and as many as 88% also present with severe, intractable pruritus. Currently, there are no approved drug treatments.
To learn more about ALGS and find resources, visit the Alagille Syndrome Alliance.
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