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Publications

The present section contains a select list of scientific publications on drug candidates in Albireo’s pipeline. The list includes titles of peer reviewed scientific journal publications and titles of oral as well as poster presentations given at scientific meetings.

A4250

Graffner, P.-G. Gillberg, L. Rikner and H.-U. Marschall
The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation
Aliment Pharmacol Ther 2016; 43: 303-310.

Anna Baghdasaryan et al.
Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis
Journal of Hepatology 2016; 64: 674–681

Per-Göran Gillberg, Erik Lindström, Taishi Hashiguchi, Yuka Shirakata, Yuya Fukui, Jan P Mattsson.
Inhibition of the ileal bile acid transporter (IBAT) by A4250 reduces hepatic damage in a mouse model of nonalcoholic steatohepatitis (NASH)
Gastroenterology 2016; 150: S1091

Elobixibat

Mats Rudling, Michael Camilleri, Hans Graffner, Jens Juul Holst and Leif Rikner
Specific inhibition of bile acid transport alters plasma lipids and GLP-1
BMC Cardiovascular Disorders 2015; 15:75

Banny S Wong and Michael Camilleri
Elobixibat for the treatment of constipation
Expert Opin. Investig. Drugs (2013) 22(2):277-284

William D. Chey, Michael Camilleri, Lin Chang, Leif Rikner and Hans Graffner.
Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation
Am J Gastroenterol, 2011; 106: 1803-12

Banny S. Wong, Michael Camilleri, Sanna McKinzie, Duane Burton, Hans Graffner and Alan R. Zinsmeister
Effects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation
Am J Gastroenterol. 2011; 106:2154–2164

Simrén, A. Bajor, P.-G. Gillberg, M. Rudling and H. Abrahamsson
Randomised clinical trial: the ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation – a double-blind study
Aliment Pharmacol Ther 2011; 34: 41–50

Per-Göran Gillberg, Mikael Dahlström, Ingemar Starke, Ann-Margret Östlund-Lindqvist
The IBAT Inhibition by A3309 – A Potential Mechanism for the Treatment of Constipation
Gastroenterology 2010; 138: S224 

A3384

RN Appleby, A Bajor, P-G Gillberg, H Graffner, M Simrén, KA Ung and JRF Walters
Effects of conventional and a novel colonic-release bile acid sequestrant, A3384, on fibroblast growth factor 19 and bile acid metabolism in healthy volunteers and patients with bile acid diarrhea
United European Gastroenterology Journal 2016; Online version available (ueg.sagepub.com)

PPAR

Stéphanie Da Silva, Åsa V. Keita, Sofie Mohlin, Sven Pahlman, Ingrid Pahlman, Johan D. Söderholm
A novel PPARγ agonist, AS002, induces PPARγ-activity in ulcerative colitis mucosa, and prevents and reverses inflammation in DSS colitis.
United European Gastroenterology Journal 2015; 3 (5 suppl.)

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